华东师范大学

讲座题目:The tumor suppressor p53, its regulation and therapeutic potential
主讲人:Zhi-Min Yuan 教授
主持人:刘明耀 教授
开始时间:2012-11-06 10:00 结束时间:讲座地址:闵行校区生科院534报告厅
主办单位:生命科学学院和科技处
报告人简介：
Zhi-Min Yuan，1993年获得美国马里兰大学生物化学博士学位，之后到哈佛医学院Dana-Farber癌症研究所任研究助理，1994年升为讲师，1998年转到哈佛大学公共卫生学院癌症细胞生物学部任助理教授，2003年晋升为遗传与复杂疾病学部副教授，2008年转到德州大学圣安东尼奥健康科学中心癌症放射疗部任放射生物学系负责人、教授，2012年后回到哈佛公共卫生学院遗传与复杂疾病学部任教授，近期已在SCI杂志上发表几十余篇学术论文。
报告简介：
Functional characterization of the p53 pathway has been a major research area of my laboratory for more than 10 years. Apart from the characterization of signals and pathways important for p53 regulation, we’ve also investigated the biological function of p53 under normal and pathological conditions. Our understanding of p53 biology has reached to the point where we are actively conducting translational research to explore the therapeutic potential of p53. Our research also involves the DNA damage responses, radiation-induced response in particular. We are interested in elucidation of the signaling mechanisms that regulate cellular response to stress and in examining how stress is converted into intracellular signals that control cell behavior in the context of carcinogenesis in general and breast cancer in particular. Our long-term goal is to gain a better understanding of the biology of carcinogenesis, which would then allow us to design effective strategies for prevention, early detection, and treatment of cancer